Académie royale de Médecine de Belgique


Résumé de Bénédicte Dubois



par Mme B. DUBOIS, MD, PhD (Départ. de Neurologie -  K.U.L.), invitée.        

Neurological diseases have a substantial and growing impact in our society. Multiple Sclerosis is one of the most common neurological disorders. Life-time risk of developing the disease is 1/500 in north-western Europe. Approximately 1.3 million individuals worldwide and 10,000 individuals in Belgium suffer from the disease. Onset of the disease typically occurs in early adulthood, between 20 and 40 years of age, at the start of building out a family and a professional career. The disease leads to significant physical and cognitive disability and hence has an important impact on the personal, social and professional life of patients and their relatives. The currently available treatments are only partially effective. The pathogenesis of the disease has not been unravelled yet, but the past years have seen exciting progress in the field. A large number of genetic risk factors have been identified, and patients differ in which combination of genetic risk factors they carry. We now are facing the challenge of translating this list of genes into an improved understanding of disease mechanisms and hopefully to better treatments.


Ont pris part à la discussion les Professeurs J.-J. Vanderhaeghen, B. Van den Eynde, G. Moonen, J.-B. Otte et Mme D. Balériaux.

Cette conférence a fait l'objet d'une publication en anglais dans les Proceedings of the Belgian Royal Academies of Medicine (PROBRAM)