Académie royale de Médecine de Belgique

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Résumé de Michel Georges (Séance du 18 décembre 2010)

 

RECENT ADVANCES IN DECIPHERING THE GENETIC ARCHITECTURE OF INHERITED PREDISPOSITION TO INFLAMMATORY BOWEL DISEASE (IBD) AND OTHER COMMON COMPLEX PATHOLOGIES.

par M. GEORGES (ULg), membre ordinaire.    

Susceptibility to common disorders such as cancer, diabetes, Alzheimer’s, myocardial infarction and inflammatory disorders including IBD, is complex, i.e. influenced by multiple environmental and genetic, possibly interacting, factors.  The proportion of disease liability that is inherited can be estimated from the phenotypic concordance between relatives (including twins) and is often found to be high.  The heritability of  Crohn’s disease, for instance, may be as high as 80%.  Until recently, however, the number and nature of genes and DNA variants underlying inherited predisposition has remained elusive.  Identifying the corresponding genes is of major interest as it reveals novel potential drug targets, and paves the way towards personlized medicine.  Recent advances in experimental (including high-throughput genotyping, sequencing and transcriptome analysis) and statistical genomics are now providing a comprehensive picture of the genetic archtecture of common, complex diseases which I will describe specifically for IBD.  

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