Académie royale de Médecine de Belgique

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Résumé de Luc Willems

 

TRANSFORMATION BY DELTA RETROVIRUSES : MECHANISMS AND THERAPIES  

par L. WILLEMS (U.Lg.), invité.        

 

Human T-lymphotropic virus type I (HTLV-1) and bovine leukemia virus (BLV) are two closely related deltaretroviruses inducing hematological diseases in human and ruminants. HTLV-1 infects about 25 million subjects worldwide and causes Adult T-cell leukemia-lymphoma (ATLL) or HAM/TSP (HTLV-induced myelopathy - tropical spastic paraparesis). BLV is the etiological agent of enzootic bovine leukemia. HTLV-1 and BLV have developed strategies to subvert hosts' immune surveillance. Understanding these mechanisms has allowed development of novel therapeutic approaches. 

Keywords: retrovirus, oncogene, histone deacetylase, vaccine, checkpoint.

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