Académie royale de Médecine de Belgique

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Vidéo et résumé de Bernard Masereel

 

IMPACT OF NANOPARTICLES ON HAEMOSTASIS

B. MASEREEL (Université de Namur – FUNDP), invité.          

Following accidental exposition, ingestion or inhalation, studies of the potential toxicity of nanoparticles (NPs) focus mainly on skin, on gastrointestinal tract, and on pulmonary system. Some studies demonstrated that NPs can be translocated to the blood compartment. Moreover the development of imaging nanoprobes, diagnostic biosensors, and medical nanodevices increases the contact and the interactions of NPs with blood components and vessel wall. As very few information challenging the NP haemocompatibility is available, we investigated the impact of different NPs on haemolysis, platelet aggregation, and thrombogenicity. The main challenge in the haemocompatibility studies is to identify the potential NP interference and overcome them to avoid false-positive and/or false-negative results. Five worldwide used NPs were selected for this study: silicon carbide (SiC), titanium carbide (TiC), silicium dioxide (SiO2), carbon black (CB) and multi-wall carbon nanotubes (MWCNT). Their haemolytic potency was evaluated as well as their impact on primary and secondary haemostasis. This work led to propose guidelines to study the NP impact on haemolysis and haemocompatibility.

 

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