Académie royale de Médecine de Belgique

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Vidéo et résumé de Marc Donath


Inflammation et diabète : doux réchauffement ou feu de l’enfer ?

par Marc DONATH (Head of the Clinic for Endocrinology, Diabetes and Metabolism – University Hospital of Basel)        

Morphological and therapeutic interventions have uncovered an inflammatory process in patients with type 2 diabetes. This inflammation is due to a pathological activation of the innate immune system by metabolic stress and is partly governed by IL-1 signaling. Initially, the inflammatory response is probably deployed to promote adaptation and regeneration. Indeed we identified a role for IL-1β and insulin in the regulation of both metabolism and immunity in response to feeding. Yet, as it becomes chronic, activation of auto-inflammatory processes may then become deleterious. It follows that modulation of inflammatory mediators may present as a possible causal therapy. This is supported by clinical studies showing that IL-1 antagonism decreases glycated hemoglobin. Furthermore, IL-1 antagonism prevents heart failure and cardiovascular diseases, the major complication of diabetes