Académie royale de Médecine de Belgique

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Résumé de Peter Kaiser (Séance du 31 janvier 2013)

TOWARDS THE SELECTION OF CHICKENS RESISTANT TO SALMONELLA AND CAMPYLOBACTER INFECTIONS

par P. KAISER (Institue for Animal Health – Royaume-Uni), invité.  

The chicken has a different repertoire of immune genes, molecules, cells and
organs compared to mammals. To understand the role of any disease resistance gene(s), it is therefore important to understand these different
repertoires, and the chicken's response to a particular pathogen. Our
studies are focused on the innate immune response, as we have demonstrated that responses of macrophages from inbred lines of chickens, and heterophils from commercial birds, correlate with resistance or susceptibility to infection with Salmonella and Campylobacter.

To map disease resistance genes, we are using a combination of expression
quantitative trait loci (eQTLs) from microarray studies, allied with whole
genome SNP arrays (WGA), copy number variation arrays and a candidate gene approach. We have recently refined the location of SAL1, a locus that defines a large component of resistance to systemic salmonellosis, from a 2 Mb region of chromosome 5, to 14 candidate genes, two of which, AKT and SIVA-1, are interesting functional candidates.

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