Académie royale de Médecine de Belgique


Résumé de Ulf Ahlgren

(Séance du 14 décembre 2012)



par U. AHLGREN (Umea University – Sweden), invité.         

Critical for pre-clinical diabetes research is the ability to monitor the 3D distribution and mass/volume of key molecular and cellular players affecting disease aetiology. Such knowledge will ultimately help address how genetic and environmental factors influence the etiology of the disease and may provide information that could be translated to the human pancreas and the development of clinical interventions. Unfortunately, the anatomical properties of the pancreas, in combination with insufficient technology, have hampered such assessments. The development of Optical Projection Tomography (OPT) has provided a new tool by which high-resolution mesoscopic imaging of the pancreas, and other challenging organs, may be performed. Our developments of the OPT imaging platform has enabled even subtle deviations in b-cell mass distribution and other cell types to be studied in the intact pancreas of rodent disease models. Recent work taking, advantage of the optical properties of tissue in the near infrared spectrum, may enable the technology to also contribute to the development of nuclear molecular imaging approaches for non-invasive b-cell scoring in animal models and humans.