Académie royale de Médecine de Belgique

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Résumé de Agnès Noël, membre titulaire


(A pris part à la discussion : le Pr K. Alitalo).

NEW INSIGHTS INTO TUMOR LYMPHANGIOGENESIS : FROM PRIMARY TUMOR TO LYMPH NODE AND INSIDE LYMPHATIC ENDOTHELIAL CELLS

par Agnès NOËL (Laboratoire de Biologie des Tumeurs et du Développement (GIGA-Cancer, ULg), membre titulaire.

Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process observed both in the primary tumor and in lymph node (LN). The lymph node status is a major determinant for cancer staging and prognosis, guiding therapeutic decisions. The drainage of tumor-derived factors through the lymphatic system to regional LN plays an important role in conditioning LN microenvironment before the arrival of disseminated tumor cells. This cross-talk between the primary tumor and LN induces profound changes in LN, elaborating a pre-metastatic niche, receptive and supportive to metastatic cancer cells. The role of this lymphangiogenic remodeling remains unclear and is studied in pre-clinical and clinical settings. For mechanistic investigation, we developed an original in vivo model reproducing the pre-metastatic lymphangiogenic niche in lymph node. Furthermore, we identified unexpected regulators that control matrix remodeling and lymphatic endothelial cell migration in a gradient of the main lymphangiogenic factor, VEGF-C.