Académie royale de Médecine de Belgique

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Résumé de Pieter Mestdagh (UGent)

long non-coding RNAs AS novel biomarkers and targets for therapy

by Pieter MESTDAGH (Center for Medical Genetics - UGent).  

The human genome is pervasively transcribed, resulting in a complex transcriptome that is dominated by non-coding RNAs. Long non-coding RNAs (lncRNAs) have gained much attention as novel players in human development and disease. Because of their cell-type or tissue restricted expression profile, they qualify as excellent biomarkers or targets for therapy. My lab is investigating the role of lncRNAs in cancer through re-analysis of publicly available RNA-sequencing data of thousands of primary tumor specimens. I will discuss the therapeutic potential of lncRNAs as well as their use as biomarkers in liquid biopsies.