Académie royale de Médecine de Belgique

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Résumé de Mattew Binns (Séance du 15 juillet 2006)

WHY SEQUENCE THE DOG GENOME ?

par M. BINNS (Royal Veterinary College of London), invité.

The domestic dog has a long and interesting evolutionary history. Throughout the period of mutual interaction, man has played a role in shaping and selecting the huge phenotypic diversity now present in the hundreds of different pedigree dog breeds produced.

The population histories of the breeds frequently involve the foundation of a breed by cross breeding small numbers of several different types, which were then selected for function or appearance. The creation of breed registries and their stud books, closed gene pools, and subsequent genetic drift, popular sire selection and intense inbreeding to meet defined breed standards have generated isolated genetic populations ideally suited for genetically mapping inherited complex traits.

The sequencing of the dog genome enables the biomedical and veterinary genetic potential of pedigree dogs to finally be unlocked. The enormous number of registered, parentage verified dogs subject to high quality veterinary care provides the genetic capital to enable pedigree dogs to become an important natural model system for the comparative genetic investigation of important complex traits that are difficult to study in man.

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